NAD ( P ) H oxidase subunit p 47 phox is elevated and p 47 phox knockout prevents diaphragm 1 contractile dysfunction in heart failure 2 3 4

NAD(P)H oxidase subunit p47 is elevated and p47 knockout prevents diaphragm 1 contractile dysfunction in heart failure 2 3 4 Bumsoo Ahn, Adam W. Beharry, Gregory S. Frye, Andrew R. Judge, Leonardo F. Ferreira* 5 6 7 Dept. of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA 8 Dept. of Physical Therapy, University of Florida, Gainesville, FL, USA 9 10 11 12 Running head: Diaphragm contractile dysfunction and p47 in CHF 13 14 15 16 17 Corresponding author 18 Leonardo F. Ferreira, PhD 19 Dept. Applied Physiology and Kinesiology 20 University of Florida 21 100 FLG Stadium Rd 22 Gainesville, FL 23 32611-8205 24 25 Phone: +1 (352) 294-1724 26 Fax: +1 (352) 392-5262 27 e-mail: [email protected] 28 29